A Good Place for Materials Scientists and Mineralogists to prepare their EM Samples

What are the main benefits that you get from using Leica EM sample preparation systems in your workflow? Imène Estève: The main advantage is that we are able to prepare and polish a large surface, free of any cracks from hardening or mechanical artefacts in the range of a couple of millimeters, where with the …

A Good Place for Materials Scientists and Mineralogists to prepare their EM Samples Read More »

Microscopes Put to the Test with Severe Conditions: ISO Standard for Resistance of Optical Instruments to Fungus and Mold Growth

The performance of optical instruments can be affected during their use by a number of environmental factors, for example, high temperature and humidity typically found in tropical climates. These factors depend on the place of use, e.g. laboratory, workshop, factory, etc., and the geographic location. Individual factors can cause a variety of effects on instrument …

Microscopes Put to the Test with Severe Conditions: ISO Standard for Resistance of Optical Instruments to Fungus and Mold Growth Read More »

First Bilateral Hand Transplant in a Child

Surgeons at The Children’s Hospital of Philadelphia (CHOP) joined with colleagues from Penn Medicine recently to complete the world’s first bilateral hand transplant on a child. Earlier this month, the surgical team successfully transplanted donor hands and forearms onto 8-year-old Zion Harvey who, several years earlier, had undergone amputation of his hands and feet and …

First Bilateral Hand Transplant in a Child Read More »

Cortical Actin Networks Induce Spatio-temporal Confinement of Phospholipids in the Plasma Membrane – A Minimally Invasive Investigation by STED-FCS

Important discoveries in the last decades have changed our view of the plasma membrane organisation. Specifically, the cortical cytoskeleton has emerged as a key modulator of the lateral diffusion of membrane proteins. Cytoskeleton-dependent compartmentalised lipid diffusion has been proposed, but this concept remains controversial because this phenomenon has thus far only been observed with artefact-prone …

Cortical Actin Networks Induce Spatio-temporal Confinement of Phospholipids in the Plasma Membrane – A Minimally Invasive Investigation by STED-FCS Read More »

Using Telecentric Optical Systems to Optimize Forensic Image Accuracy and Reproducibility

When the first compound microscopes were invented in 1590, scientists marveled at their new ability to see tiny objects and features that were previously invisible to the eye and therefore seemingly nonexistent. Ever since then, the study of these miniscule details has brought science into a forensic world once ruled by intuition and deduction. The …

Using Telecentric Optical Systems to Optimize Forensic Image Accuracy and Reproducibility Read More »

A Lipid Bound Actin Meshwork Organizes Liquid Phase Separation in Model Membranes

The eukaryotic cell membrane is connected to a dense actin rich cortex. We present FCS and STED experiments showing that dense membrane bound actin networks have severe influence on lipid phase separation. Our results reveal a mechanism how cells may prevent macroscopic demixing of their membrane components, while at the same time regulate the local …

A Lipid Bound Actin Meshwork Organizes Liquid Phase Separation in Model Membranes Read More »

Sony Design: MAKING MODERN Event Report / Events / News / Sony

Event Report Commemorating the Publication ofSony Design: MAKING MODERN To celebrate the publication of Sony Design: MAKING MODERN, an exhibition was organized at the Sony Building in Ginza. A pre-event talk was held on April 28. Joining head of Sony Design Yutaka Hasegawa to discuss the spirit of Sony Design and enduring appeal of Sony …

Sony Design: MAKING MODERN Event Report / Events / News / Sony Read More »

Workflows & Protocols: How to Use a Leica Laser Microdissection System and Qiagen Kits for Successful RNA Analysis

All samples (A–D) with different treatments have almost the same quantity, only sample C (fixed, stained and picked directly from slide) shows higher quantity than positive control (sample A). No influence from EtOH fixation, staining or Leica LMD dissection detectable. Cryo-storage of slide in a Parafilm-sealed 50 ml Falcon tube at –80 °C overnight, gently thawed step-wise for …

Workflows & Protocols: How to Use a Leica Laser Microdissection System and Qiagen Kits for Successful RNA Analysis Read More »