Month: March 2018

Nikon | News | Nikon Corporation and Yumanity Therapeutics Enter Contract for the Commission Development of Drug Discovery Assay System in Neurodegenerative Diseases

March 28, 2018 Nikon Corporation (President: Kazuo Ushida, Minato-ku, Tokyo) and its subsidiary Nikon Instruments Inc. (President: Toshiaki Nagano, Headquarters: Melville, NY, USA) and Yumanity Therapeutics, a company focused on transforming drug discovery for diseases caused by protein misfolding, (CEO: Tony Coles, Headquarters: Massachusetts, USA (hereinafter “Yumanity Therapeutics”)) have concluded a contract (hereinafter “this contract”) …

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What is FLIM – Fluorescence Lifetime Imaging?

Fluorescence lifetime as probe for nano-environment This lifetime is a characteristic parameter of each fluorescent dye that may change with its micro-surrounding or its conformational state. Lifetime information probes the molecular environment for its composition, such as ion concentration, pH, lipophilicity or the binding to other molecules. Combination of lifetime measurement and imaging FLIM combines …

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SP FLIM – Spectral Fluorescence Lifetime Imaging

Spectral freedom with SP8 FALCON FALCON, based on the well accepted Leica SP-detector, ensures optimal adjustment to experimental conditions and removal of autofluorescence. The fluorescence light is split spectrally by a prism and the spectral fractions reach the detectors. Software-controlled mirror sliders in front of the detector select the wavelength range of interest. This gives the freedom and …

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Solvent immersion imprint lithography

We expand upon our recent, fundamental report on solvent immersion imprint lithography (SIIL) and describe a semi-automated and high-performance procedure for prototyping polymer microfluidics and optofluidics. The SIIL procedure minimizes manual intervention through a cost-effective (∼$200) and easy-to-assemble apparatus. We analyze the procedure’s performance specifically for Poly (methyl methacrylate) microsystems and report repeatable polymer imprinting, …

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