Month: February 2017

Any Surface – Design concept for IoT & Agent / Stories / Sony Design / Sony

Breathing new life—and new meaning—into basic elements “A musician aims to play sounds that transcend silence, while a painter strives to paint beauty that transcends a white canvas.” Transcending the state of nothingness—that’s what art is. In the creative process, the moment that defines a work often comes at the initial encounter between the artist …

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Human NK Cell Development Requires CD56-mediated Motility and Formation of the Developmental Synapse

While distinct stages of natural killer (NK) cell development have been defined, the molecular interactions that shape human NK cell maturation are poorly understood. Here we define intercellular interactions between developing NK cells and stromal cells which, through contact-dependent mechanisms, promote the generation of mature, functional human NK cells from CD34+ precursors. We show that …

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Testing the Münch Hypothesis of Long Distance Phloem Transport in Plants

Long distance transport in plants occurs in sieve tubes of the phloem. The pressure flow hypothesis introduced by Ernst Münch in 1930 describes a mechanism of osmotically generated pressure differentials that are supposed to drive the movement of sugars and other solutes in the phloem, but this hypothesis has long faced major challenges. The key …

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Video Talk by Kurt Thorn: The Abbe Diffraction Experiment

This lecture describes the famous experiments of Ernst Abbe which showed how diffraction of light by a specimen (and interference with the illuminating light) gives rise to an image and how collection of diffracted light defines the resolution of the microscope. These concepts are demonstrated by using a diffraction grating as a specimen and visualizing …

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The Molecular Architecture of Hemidesmosomes as Revealed by Super-Resolution Microscopy

Hemidesmosomes have been extensively studied by immunofluorescence microscopy, but due to its limited resolution, their precise organization remained poorly understood. We studied hemidesmosome organization in cultured keratinocytes by 2- and 3-color super-resolution microscopy. We observed that in the cell periphery, nascent hemidesmosomes are associated with individual keratin filaments and that β4 is distributed along rather …

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How to Turn Microscope Workplaces Ergonomic

Microscopes are demanding when it comes to the working posture. Observing samples requires full concentration and looking through the eyepieces usually involves inclining the head and back, so that one’s eyes, neck, shoulders are properly positioned. This can, in some cases, cause the operator to suffer from strain. Once a microscope user feels physical discomfort, …

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Chronic Stress in Mice Remodels Lymph Vasculature to Promote Tumour Cell Dissemination

Chronic stress induces signalling from the sympathetic nervous system (SNS) and drives cancer progression, although the pathways of tumour cell dissemination are unclear. Here we show that chronic stress restructures lymphatic networks within and around tumours to provide pathways for tumour cell escape. We show that VEGFC derived from tumour cells is required for stress …

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Actin-Dependent Vacuolar Occupancy of the Cell Determines Auxin-Induced Growth Repression

The cytoskeleton is an early attribute of cellular life, and its main components are composed of conserved proteins. The actin cytoskeleton has a direct impact on the control of cell size in animal cells, but its mechanistic contribution to cellular growth in plants remains largely elusive. Here, we reveal a role of actin in regulating …

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