Previously, the preferred way to study the subtlest elements of the kidney, such as foot processes and the slit diaphragm has been by the use of electron microscopy. Using STED microscopy, we show that the nanoscale localization of slit diaphragm proteins can now be resolved using light microscopy. Even if the nanoscopic resolution has been …
Fast FRAP experiments need a sufficient number of measurement points for meaningful interpretation and fitting analysis. To study very fast translocational processes, the use of a resonant scanner (RS) is preferred. The advantage in using FRAP with the RS is that statistics are much better in experiments that require fast acquisition: If the half time …
The results of this study show that early (perinatal [30]) Wnt4 expression is functionally important [17]. Further results indicated that canonical Wnt signaling in the myoepithelium requires PR and Wnt4, whereas the canonical Wnt signaling activities observed in the embryonic mammary bud and in the stroma around terminal end buds are independent of Wnt4 [17]. In addition, data …
Enhancing value across generations What goes into developing a camera lineup that keeps users coming back time and time again? It’s all about balance: taking advantage of innovations in camera technology to provide new shooting experiences but at the same time delivering solid, dependable usability and design qualities that find a special place in users’ …
Although interferometry may once have been dismissed by the medical community because of its inability to see inside the human body, its application within the wider biomedical arena is continuing to grow and evolve; so much so that the technique is now used in the production of prosthetic limbs, research in dentistry and even for …
For the past several years, digital microscopy has been shown to be useful for inspection, quality control and assurance (QC/QA), and failure analysis (FA) in the microelectronics industry, especially for printed circuit boards (PCBs). Recently, state-of-the-art improvements have made digital microscopy even more powerful and practical for inspection, leading to a more efficient workflow. Here, …
Historically, light microscopy has been limited in its ability to resolve closely spaced objects, with the best microscopes only able to resolve objects separated by 200 nm or more. This limit is known as the diffraction limit. How to break this fundamental law of physics and win a Nobel Prize to boot: In this nature …
