Month: December 2013

The Relationship Between Membrane Potential and Calcium Dynamics in Glucose-Stimulated Beta Cell Syncytium in Acute Mouse Pancreas Tissue Slices

Oscillatory electrical activity is regarded as a hallmark of the pancreatic beta cell glucose-dependent excitability pattern. Electrophysiologically recorded membrane potential oscillations in beta cells are associated with in-phase oscillatory cytosolic calcium activity ([Ca2+]i) measured with fluorescent probes. Recent high spatial and temporal resolution confocal imaging revealed that glucose stimulation of beta cells in intact islets …

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Super-Resolution Microscopy Gives New Insights into Nuclear Pore Complex Organization

The Nuclear Pore Complex (NPC) is a large protein complex in the nuclear membrane, representing the gate to the eukaryotic genetic makeup. This complex consists of several hundreds of proteins which form a selective gate for compounds destined to enter or leave the nucleus. Because of this outstanding function the structure of the NPC is …

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Laser Microdissection (LMD) and Fancy Applications

Fig. 1: Reference grid imprinted onto the cell culture substrate. (A) Scheme of the reference grid for the laser microdissection microscope. The patterned aclar substrate was imaged under an epifluorescence microscope using excitation filters BP 545/30 (B), BP 480/40 (C) and BP 360/40 (D). The grid fluorescence is much fainter than the GFP signal of tagged proteins. (E) The reference grid is visible …

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Good Design Award 2013 / Awards / News / Sony Design / Sony

Jury Comments Greater demand is expected in surface-mount technology, and this line addresses needs across the board with a solder paste printer, electronic part mounter, and visual inspection machine. Here, addressing functional needs—in the required work and quality, operator efficiency, and ease of handling—and seeking an uncluttered, beautiful appearance has yielded industrial design with a …

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